Preclinical Radioligand Therapy to Advance Radiopharmaceuticals

From radiolabeling and biodistribution to dosimetry and efficacy in diverse animal models, Perceptive Discovery delivers integrated, translatable data to accelerate your radiopharmaceutical pipeline from concept to clinic.

The Leading Preclinical Imaging Partner for Radiopharmaceutical Development

Perceptive Discovery offers comprehensive preclinical RLT services to support the discovery and development of radiopharmaceutical therapies. We work with biotech and pharmaceutical teams to design and execute custom studies that generate the translational data needed for IND submission and clinical advancement.

Our team of radiochemists, pharmacologists, cancer biologists, and imaging scientists bring deep expertise across a broad spectrum of isotopes, modalities, and therapeutic platforms. Whether developing a novel targeted radiotherapeutic or a companion diagnostic, we streamline radiolabeling, dosimetry, efficacy, and image analysis—all under one roof.

With over 900+ preclinical RLT studies supported, and 50+ IND-enabling dosimetry studies, we are a proven partner in bringing first-in-class radiopharmaceuticals to the clinic.

A Proven Leader in Preclinical RLT Program Delivery

  • Global infrastructure: 6 preclinical labs with integrated radiochemistry centers
  • Full suite of multi-modality imaging: PET, SPECT, MRI, CT, IVIS, CFT
  • Experience across tumor types and administration routes
  • Extensive Alpha/Beta Emitter experience:
    • Alpha Emitters: 225Ac, 212Pb, 211At
    • Beta Emitters: 177Lu, 67Cu, 161Tb, 131I, 90Y

End-to-End Support for Radiopharmaceutical Development

How Can We Help?

Reach out today and one of our solution experts will be in touch to learn about your specific needs.

Radiolabeling & Chemistry Services

  • Custom radiolabeling of small molecules, peptides, antibodies, nucleic acids, cells, and nanoparticles
    • Isotope platforms for PET, SPECT, and therapy: 18F, 89Zr, 64/67Cu, 68Ga, 177Lu, 225Ac, 212/203Pb, 131/125I, 211At
    • Chelation chemistry and isotope pairing for theranostic applications
    • In-house purification, QC, and stability testing
  • Biodistribution & PK/PD Imaging
  • Quantification of tumor and tissue uptake using matched diagnostic/therapeutic pairs (e.g., 203Pb/212Pb, 89Zr/225Ac, 111In/225Ac, 18F/211At)
  • Evaluate systemic distribution, target specificity, and clearance
  • Longitudinal studies across small and large animal models utilizing multiple routes of administration

Dosimetry & IND-Enabling Studies

  • Regulatory-grade dosimetry using direct and surrogate isotope imaging
  • Species: mouse, rat, NHP (cynomolgus monkey)
  • Dose estimation and organ toxicity prediction
  • Evaluation of radionuclide daughter translocation and clearance

Efficacy in In Vivo Tumor Models

  • Monitor tumor regression and survival outcomes
  • Assess in-life and endpoint toxicity with hematology (CBC) and clinical chemistry biomarkers
  • Compare candidate efficacy to standard of care
  • Correlate therapeutic response with dosimetry and biomarker expression

Anti tumour-muc-1 antibody labelled with DOTA and imaged in mice using 111In.
Kelly V.J. et al Theranostics 2020, Vol. 10, Issue 15

Mice treated with 225Ac-labelled anti tumour-muc-1 antibody A) Tumor volume in animals administered with 225Ac-DOTA-hTAB004 (red) compared to control animals administered DOTA-hTAB004 (blue) as monitored for the duration of the study. Intra-group comparisons of percentage change in tumor volume at each study day; * P<0.05, # P<0.01, ^ P<0.001. (B) Kaplan-Meier survival curves showing 100% survival in treatment group until the end of the study (D=48; red) and 0% survival in control group (blue). Kelly V.J. et al Theranostics 2020, Vol. 10, Issue 15

Ready to Advance Your Radiopharmaceutical Pipeline?

Let’s design a translational imaging strategy to de-risk development and accelerate your radioligand therapy program.

Discover Our Clinical Trial Imaging Solutions

In-House Clinical and Imaging Centers

Highly established clinical and imaging centers supporting first-in-human and multicenter studies.

Imaging Core Lab

Proven expertise in delivering high-quality clinical trial imaging data at a global scale.