Clinical Radioligand Therapy / Radiopharmaceutical Services

Radioligand therapy (RLT) may be new to some, but at Perceptive Imaging, nuclear medicine is in our DNA.

In a field where precision is everything, the cost of inexperience is high. Missteps in isotope selection, imaging protocols, or dosimetry strategy can derail timelines, compromise data integrity, and put patient safety at risk. That’s why 80% of sponsors trust Perceptive: we bring the scientific rigor, operational depth, and regulatory foresight needed to de-risk your RLT program — end to end.

We support the full lifecycle of theranostics and radioligand therapy trials — ensuring patient safety from early-phase dose optimization and biodistribution through global Phase III execution. With the right infrastructure, scientific expertise, and advanced imaging technology, we deliver high-quality data that accelerates development timelines and drives regulatory success to help you bring life-saving treatments to patients in need.

Radiopharmaceutical Experience and Scalability You Can Trust

Perceptive is the industry’s most experienced imaging partner in radioligand / radiopharmaceutical therapy (RPT), supporting over 80 clinical trials and thousands of preclinical programs across a wide range of targets and tumor types.

We understand the operational complexity of radioligand therapy trials — and we’ve built the systems, teams, and partnerships to manage them at scale.

Whether you’re launching a first-in-human Ph 0 study or scaling a global Phase III, Perceptive offers a full suite of clinical imaging services tailored to radiopharmaceutical trials.

Our experience covers:

• Site selection and qualification • Blinded Independent Central Review (BICR) • Imaging charter development (including for IND Submission) • Standard of Truth (SoT) panel management
 • Tracer supply chain logistics and vendor coordination • Real-time image QC and data transfer
 • Reader training and monitoring • Regulatory support for IND/CTA submissions
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Global Nuclear Medicine Site Network and Setup

Site readiness is one of the most critical success factors in radioligand therapy trials. Perceptive has built the industry’s most robust site qualification and training infrastructure:

2,000+ PET/SPECT imaging centers qualified globally

Decades of experience in complex site setup, bringing new isotopes online

>99% of scans deemed evaluable across studies

Rigorous phantom-based qualification, dose calibration and harmonization workflows

Experience in working with variety of phantoms, including NEMA, Uniformity and Jaszczak.

Experienced logistics team ships Perceptive-owned phantoms to sites

Flexible training, teleconferences, web-based training and on-demand support.

Real-time QC of first-subject scans and continuous feedback loops.

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Molecular Imaging Services: PSMA-PET Imaging, FAPI-PET Imaging, and beyond

Perceptive Imaging offers deep expertise in molecular imaging across different types of cancer, with a proven track record in PSMA-PET trials and a growing portfolio of support for emerging radioligand targets. Our team has helped shape the imaging standards for PSMA-based therapies and continues to lead innovation in tracer development, segmentation analytics, and trial design.

We are actively supporting clinical trials in a wide range of novel targets, including FAP, DLL3, HER2, GRPR, MC1R, STEAP1, TROPE2, PTK7, CAIX, and more. Whether you’re working with established tracers or pioneering new theranostic pairs, our imaging infrastructure and scientific leadership will give you confidence in the accuracy, reproducibility, and regulatory-readiness of your data, as you move forward in bringing new treatments, and hope, to the patients who need it the most.

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Advanced Medical Image Analysis and Dosimetry Services

Radiopharmaceutical therapies represent hope for many cancer patients and their loved ones, so the studies that support them require an understanding beyond just standard imaging. Since these therapies offer so much hope, and patient safety is at stake, it is absolutely critical you choose an imaging partner with deep understanding of tracer kinetics, organ-specific uptake, and radiation dose safety.

With the patient at the forefront of everything we do, our dedicated dosimetry and analytics teams bring unmatched expertise to every study:

60+ dosimetry studies supported across isotopes and indications

40-person advanced analytics and 10-person dosimetry teams

Organ- and tumor-specific dose estimates using validated models (e.g., OLINDA) and custom in-house tools

Support for multi-center, pediatric, and translational studies

Expertise across isotopes including Ac-225, Lu-177, Pb-212, Cu-64/67, Zr-89, and more

Driving Imaging Innovation with AI

Perceptive is the only imaging core lab to date to support a radioligand therapy FDA submission using AI-derived quantitative PET data. Our proprietary PSMA segmentation platform, updated in April 2025, delivers:

  • Fully automated segmentation of both bone and soft tissue lesions
  • Dynamic thresholding within patients for improved accuracy across lesion types
  • Anatomical labeling of lesions for enhanced interpretability
  • Reduced human processing time and improved reproducibility

This tool was developed and validated in the context of the VISION trial, and continues to evolve with new capabilities for emerging tracers and disease states.

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PSMA Tracer Management and Distribution Services

Perceptive Imaging offers centralized PSMA tracer management and distribution services to simplify logistics and reduce site burden in radioligand therapy trials. Our team provides end-to-end oversight of tracer supply across global clinical sites, ensuring timely delivery, consistent communication, and seamless integration with imaging workflows.

Our services include:

• Oversight of tracer production and delivery schedules • Coordination with manufacturing and distribution partners • Study-specific communication and escalation plans • Site training on ordering, handling, and documentation • Invoice reconciliation and supply chain reporting • Real-time issue resolution and delivery tracking

Seamless Integration from Preclinical Programs

Perceptive also offers comprehensive preclinical RPT services through our Discovery team – a trusted partner for advancing radiopharmaceuticals from concept to clinic.
Perceptive Discovery delivers precise, translatable multi-modality imaging data to accelerate your program, including:

  • Radiochemistry development and radiolabeling
  • Biodistribution and PK studies across species
  • Efficacy modeling in tumor-bearing animals
  • Dosimetry modeling and extrapolation to human safety margins
  • Bioequivalency studies to support imaging-to-therapy transitions
  • IND-enabling packages and regulatory strategy
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How Can We Help?

Reach out today and one of our solution experts will be in touch to learn about your specific needs.

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