Obesity and Weight Loss

Capture Body Composition Imaging Biomarkers with Confidence

 

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Meeting Today’s Obesity Trial Needs

The development of GLP-1 agonists and other therapies for weight loss and obesity is evolving and so is the advancement of imaging biomarkers for body composition profiling. The options to delineate and quantify muscle and lean mass are getting more sophisticated, so determining which imaging modality, anatomical coverage, and analysis methods to use can be critical to your obesity clinical trial outcomes.

Perceptive Imaging combines the right experience and the right people to help you navigate the nuances of imaging in weight loss clinical trials and to drive the success of your development program.

Image credit: AMRA Medical

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Perceptive Imaging Experience

Perceptive has provided imaging services to quantify lean and/or adipose tissue in nearly 80 clinical trials to date, contributing to 8 regulatory approvals.

You can rely on the scientific experts at Perceptive Imaging to identify the appropriate techniques to meet your weight loss clinical trial objectives. Their in-depth understanding of the different modalities involved in body composition imaging, including DXA, CT, and MRI and can help you reliably measure muscle and fat changes in the whole body or at specific anatomic locations.

Learn why you can rely on Perceptive Imaging for your obesity clinical trials.

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Perceptive’s expertise spans the gamut of imaging that’s required to demonstrate safety and efficacy during obesity clinical trials, including:

 

  • Whole body lean and fat mass (DXA)
  • Subcutaneous and visceral fat (DXA. MRI or CT)
  • Intramuscular fat fraction (MRI)
  • Muscle volume (CT or MRI)
  • Liver, spleen or pancreatic volume
  • Liver, pancreas or spleen fat fraction
  • Cardiac safety (MRI or ECHO)
  • Bone age (X-ray)
  • Bone density (DXA BMD)
  • Functional brain changes (fMRI)

Learn more about Perceptive’s expertise in weight loss clinical trial imaging

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Clinical Adjudication in Obesity Trials

Independent clinical event adjudication of efficacy and safety endpoints in obesity trials is essential to fully understand the potential benefits and risks of GLP-1 agonists and other treatments beyond the loss of weight.

Perceptive’s Clinical Adjudication team has a combined 60 years of experience managing and supporting clinical event adjudication services, including extensive work in several obesity trials. Our robust, regulatory-compliant, efficient processes can help you mitigate the challenges associated with adjudicating efficacy and safety endpoints in obesity and weight loss trials.

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Resources

Stay on top of industry trends and learn how Perceptive is helping sponsors and CROs design and implement obesity clinical trials effectively – and efficiently.

Imaging for Body Composition Trials: Opportunities and Considerations

Imaging in Metabolic and Body Composition Trials

Clinical Adjudication in Obesity Trials