Perceptive - Your Comprehensive Imaging Partner for Alzheimer's Research

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Maximize the success of your AD trials with Perceptive

With over 20 years of neuroimaging experience in Alzheimer’s disease (AD), Perceptive is a leader in advancing PET and MRI imaging biomarkers for drug development and clinical research. Our global multi-center imaging trial management services include radiotracer supply, centralized data management, and advanced analysis as well as visual reads of imaging endpoints. 

Developing novel CNS therapies is a complex endeavor, requiring scientific rigor, medical expertise, and operational excellence. Our proven track record in supporting CNS studies reflects our commitment to transforming healthcare through innovative imaging and informatics. 

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Highlights of Our Expertise:

  • Radiotracer supply network featuring commercial and non-commercial imaging agents 
  • Proprietary Imaging Platforms 
  • Perceptive In-House Clinical imaging sites in the US and UK specializing in Phase I-II trials 
  • GMP labeling of novel drugs and biomarkers with C-11 and F-18 
  • Highly specialized early-phase data acquisition, analysis, and interpretation 

370+

AD imaging trials managed

40,000+

subjects imaged

150+

AD imaging studies

90+

multi-center Phase II-III trials

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Late Phase Services

  • Validated PET and advanced MRI pipelines.  
  • IQ Analytics Imaging platform for increased power of studies.   
  • Complete project support from study design to imaging site qualification and management to data analysis.  
  • Quantitative analysis for monitoring drug effects.  
  • Semi-qualitative neuro-radiology reads for eligibility, safety and efficacy assessments including ARIA, amyloid and tau.   
  • Image triage, preprocessing and management solutions.  
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Advanced Imaging Biomarker Analytics

Perceptive provides a broad range of imaging endpoints and advanced image analytics for Alzheimer’s research: 

PET Imaging

  • SUV & SUVr 
  • Centiloid 
  • AmyloidIQ 
  • TauIQ

MR Imaging

  • 3D Volumetric imaging (T1) 
  • Diffusion-weighted imaging (DWI) 
  • Arterial spin labeling (ASL) 
  • Resting-state fMRI (rsfMRI) 

Amyloid-β (Aβ) and Tau Biomarker Expertise

Amyloid-β (Aβ) and tau are pivotal biomarkers in AD clinical trials due to their central role in disease pathogenesis. Utilizing specific PET radioligands, we measure misfolded protein concentrations to provide imaging endpoints for patient stratification and pharmacodynamic assessments, enabling enhanced decision-making in drug development. 

AmyloidIQ

Developed through the spatio-temporal analysis of extensive neuroimaging datasets, AmyloidIQ quantifies the global amyloid burden in the brain. It surpasses other amyloid quantification algorithms in both stratifying subjects for clinical trials and monitoring therapeutic interventions. 

TauIQ

Building on AmyloidIQ’s framework, TauIQ quantifies both global and local tau deposition, addressing the complexity of tau accumulation in AD. It outperforms SUVr methods in cross-sectional and longitudinal analyses. 

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Why Choose Perceptive?

Unmatched Expertise:

Over two decades of specialized experience in imaging biomarkers for AD. 

Advanced Technology:

Cutting-edge tools like AmyloidIQ and TauIQ as well as advanced MRI approaches for superior analysis and decision-making.

Comprehensive Services:

From early-phase trials to late-stage studies, we provide end-to-end support for imaging and biomarker development.

Global Reach:

A robust radiotracer supply network coupled with global imaging footprint to serve the sites and the study teams. 

Collaborative Approach:

We work closely with academic institutions, pharmaceutical companies, and research organizations to drive progress. 

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How Can We Help

Reach out today and one of our solution experts will be in touch to learn about your specific needs.