Astatine-211 for Targeted Alpha Radiotherapy and Drug Development
Synonyms: Astatine-211, ²¹¹At, At-211, alpha emitter, targeted alpha therapy (TAT), alpha radiotherapy, radiolabeled small molecules, radiolabeled peptides, radiopharmaceutical research, alpha particle isotope, radioligand therapy
Astatine-211 (²¹¹At) is an alpha-emitting radioisotope with unique potential in targeted alpha therapy (TAT) for cancer and other diseases requiring high-precision cytotoxicity. Its short-range, high-linear energy transfer (LET) alpha particles enable the selective destruction of malignant cells while minimizing damage to surrounding healthy tissue. In preclinical and translational research, ²¹¹At is often conjugated to small molecules, peptides, or other targeting vectors to evaluate therapeutic efficacy and dosimetry in novel drug candidates.
Astatine-211 (²¹¹At) Details:
Radiation Type: Alpha emitter (energy ~5.87 MeV)
Half-life: ~7.2 hours – suitable for targeted delivery and rapid clearance
Primary Applications:
- Targeted alpha therapy for hematologic malignancies and solid tumors
- Radiolabeling of small molecules and peptides
- Preclinical pharmacokinetics, biodistribution, and efficacy studies
Benefits in Drug Discovery:
- High-LET radiation for potent tumor cell killing
- Short path length (~70 µm) reduces off-target toxicity
- Versatility in conjugation chemistry for diverse targeting agents
- Suitable for both early-stage preclinical validation and translational studies
- Potential for theranostic pairing with iodine isotopes for imaging
Learn more about our preclinical radiopharmaceutical services
Request Additional Data
Reach out today and one of our solution experts will be in touch to learn about your specific needs.