Understanding biodistribution is a cornerstone of preclinical drug development, offering vital insights into a compound’s targeting, accumulation, and clearance within the body.
Our tailored services bridge preclinical research to clinical trials, delivering critical insights for go/no-go decisions.
Your trusted partner in biodistribution research
Our radiochemistry team brings extensive expertise in both diagnostic and therapeutic radionuclides, having successfully radiolabeled hundreds of compounds for preclinical biodistribution studies, including radioligand therapies. These include antibodies, peptides, small molecules, viruses, cells, and more. This experienced team possesses the specialized knowledge needed to support optimization and synthesis of radiolabeled compounds for rapid clinical translation.
Perceptive Discovery’s in-house pharmacology team leverages surgical expertise to generate a variety of preclinical research models. Specializing in neurology and oncology, we support a wide range of disease models and administration routes tailored to study-specific needs. We develop and manage animal models, from small rodents to non-human primates, to provide relevant, translatable biodistribution data across therapeutic areas.
Our sites include state-of-the-art imaging facilities with all major preclinical in vivo imaging modalities available, including PET, SPECT, CT, MRI, Optical and Ultrasound imaging. To complement the in vivo imaging data, we can also provide ex vivo biodistribution techniques including gamma counting, cryo-fluorescence tomography (CFT), autoradiography, immunohistochemistry and histology.
Together this allows for 2D and 3D imaging and visualization of targeting, kinetics, and whole-body biodistribution and macro and micro resolution. From molecular intricacies to whole-body complexity, we leverage cutting-edge imaging tools to empower studies with precise, actionable insights.
Our advanced analytics team supports various preclinical image analysis tasks for biodistribution studies, including quantification of the target compounds in appropriate regions of interest in the subjects, adjusting our approach based on species involved, imaging modalities, and therapeutic focus. Our automated and semi-automated workflows allow for fast, reproducible analysis tailored to provide needed insight for the study at hand. The team can also offer dosimetry services with calculations across radionuclide, administration route, and species.
Our Scientific and Medical Services (SMS) team oversee the translation of sponsor preclinical programs into the clinic, offering scientific advice and expertise on program design and regulatory requirements, to ensure continuity for our clients and a seamless transition to our clinical teams.
We are imaging modality agnostic, applying techniques across therapeutic areas and species. Whether your study is single or multimodal, with multiple isotopes or contrast mechanisms, our team is ready to deliver tailored solutions.
Contact us to discuss your research needs and explore how we can support your next study.
