Combination Strategies to Improve Radioligand Therapy Efficacy

A practical guide to preclinical RLT combination therapy development

Radioligand therapy (RLT) is rapidly advancing oncology treatment, but challenges including target heterogeneity, treatment resistance, variable tumor dose, and normal-tissue toxicity can limit therapeutic response. RLT combination therapies offer an opportunity to address these barriers through mechanism-based approaches designed to improve efficacy and expand the therapeutic window.

This ebook explores strategies for combining RLT with immunotherapy, DNA damage response inhibitors, radiosensitizing therapies, external beam radiotherapy, and other targeted approaches. It also examines the preclinical considerations needed to evaluate these combinations, including model selection, dose and treatment sequence, quantitative imaging, biodistribution, dosimetry, biomarkers, and efficacy endpoints.

Learn how a mechanism-driven preclinical RLT development strategy can help generate stronger translational evidence and inform decisions as radioligand therapy programs move toward the clinic.

From preclinical model selection and radiochemistry through in vivo imaging, biodistribution, dosimetry, quantitative image analysis, and translational strategy, Perceptive Discovery supports the evidence needed to evaluate radioligand therapy combination strategies and advance promising RLT programs toward clinical development.

Explore Perceptive Discovery’s radioligand therapy capabilities