Preclinical Imaging

Preclinical Imaging and In Vivo Imaging Expertise for Drug Development

Harness Advanced Preclinical and In Vivo Imaging for Faster, More Informed Decision-Making

Accelerate your research with Perceptive Discovery’s best-in-class preclinical imaging and in vivo imaging services. Our integrated approach across early-phase R&D enables you to generate high-quality data earlier, improving decision-making and streamlining your development timeline. By leveraging our advanced imaging capabilities, you can quickly identify the most promising compounds, reduce risk, and optimize study design for maximum impact.

15+

Years of experience

Over 3K

Studies supported

8

Preclinical labs

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Why Choose Perceptive Discovery for Preclinical and In Vivo Imaging?

Premier Scientific Service

A trusted partner delivering advanced preclinical imaging and in vivo imaging solutions, supported by expertise in radiochemistry, custom experimental design, flawless execution, and insightful results interpretation.

Diverse Capabilities Across Therapeutic Areas

Our adaptable approach enables specialized imaging biomarker studies across oncology, neuroscience, radiopharmaceutical therapy, and more, ensuring your in vivo imaging studies address the unique needs of each therapeutic area.

Global Research Infrastructure

With multiple imaging facilities and strategic collaborations, we provide agile study management, expanded capabilities, and the scalability to meet complex preclinical imaging requirements.

Collaborative Focus

We work as an extension of your team, fostering transparent communication and long-term partnerships that drive successful imaging outcomes.

Advanced Analysis Methods

Our bespoke image analytics pipelines and cutting-edge tools deliver precise, reproducible insights—transforming complex in vivo imaging data into actionable results

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Key Therapeutic Areas

Neuroscience

Perceptive Discovery has vast preclinical experience supporting Neuroscience drug development. Our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as:

  • Biodistribution
  • Target engagement and occupancy
  • Neuropharmacodynamics
  • Neurotransmitter release
  • Biological therapeutics pharmacokinetics
  • Neuroinflammation
  • Neuromodulator analysis

Oncology

We use state-of-the-art imaging techniques to characterize the behavior of novel therapies and identify imaging biomarkers across diverse tumor model types (e.g. subcutaneous, orthotopic, metastatic).

Our core capabilities include:

  • Biodistribution of test articles
  • Target density and engagement
  • Pharmacokinetics (PK)
  • Pharmacodynamics (PD)
  • Tumor growth properties
  • Therapeutic efficacy

Radiopharmaceutical Therapy & Theranostics

Perceptive partners with sponsors to advance radiopharmaceutical therapy from proof-of-concept through late-phase trials. Our preclinical expertise in primary in vivo pharmacology services, radiochemistry, biodistribution, and dosimetry services supports optimized therapy development and accelerates progress toward first-in-human studies.

Our core capabilities include:​

  • Proof-of-concept studies to evaluate tumor targeting and anti-tumor activity
  • Radiolabeling and immunoreactivity method development for alpha, beta, and gamma isotopes
  • Biodistribution and dosimetry studies using imaging, gamma counting, and advanced analyses
  • Tailored clinical trial strategies focused on radiation safety, dosimetry, and patient selection
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Modalities and Models for Advanced Preclinical and In Vivo Imaging

Perceptive Discovery delivers a full spectrum of preclinical imaging services designed to generate high-fidelity data and actionable insights, empowering more confident decision-making at every stage of drug development.

From the molecular level to complex whole-body systems, our team harnesses advanced in vivo imaging technologies to develop and validate imaging biomarkers, ensuring every study is equipped with the most relevant and translatable tools.

We utilize a diverse portfolio of animal models ranging from small rodents to non-human primates (NHPs) to maximize translational relevance. Each model is carefully selected, developed, and managed to provide

Our In vivo imaging and tissue/cell-based assays include:
In vivo Tissue/cell-based PET Autoradiography and microautoradiography SPECT Optical 2D and 3D cryotomography MRI Cryofluorescence tomography (CFT) Bioluminescence Blood and urine analysis Ultrasound Flow cytometry (FACS) Radioligand binding assay (cells and tissues)
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Expert Radiochemistry Services for Preclinical and Translational Studies

Radiolabeled compounds are essential for non-invasive evaluation of drug distribution, metabolism, and pharmacokinetics using PET and SPECT. Perceptive Discovery’s deep expertise in optimizing and synthesizing radiolabeled compounds ensures that preclinical imaging and in vivo imaging studies are performed with the highest levels of scientific rigor, accuracy, and safety. This precision-driven approach accelerates drug development by delivering reliable data that supports informed decision-making in both preclinical and translational research.

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Image Analysis

Perceptive’s medical image analysis team specializes in developing advanced algorithms and pipelines to tackle complex image science challenges, extracting precise quantitative data for studies ranging from discovery research to late-phase clinical trials.

By combining the latest advancements in image science with engineering expertise, we innovate and refine new algorithms and automated and semi-automated image analysis processes
to ensure efficient, reliable analysis.

We support a range of preclinical image analysis tasks, tailoring our approach based on the species, imaging modalities, and therapeutic focus. Using our in-house software, including VivoQuant and iPACS, we apply existing tools or develop new ones to meet the specific needs of each study while offering sponsors convenient access to image data and results.

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VivoQuant: Advanced Image Processing and Analysis Software for Early Drug Development

VivoQuant is a powerful, vendor-neutral imaging software designed to deliver seamless image post-processing and 
analysis across multiple modalities and species. Engineered through collaboration with scientists, for scientists, VivoQuant empowers researchers by combining fundamental viewing functionality with powerful tools for fine-tuning images and isolating and analyzing regions of interest for quantitative 
analysis tailored to preclinical workflows.

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From Bench to Bedside: Discover Our In-House Imaging Clinics

With Perceptive’s translational imaging expertise, sponsors benefit from coordinated imaging protocol development across preclinical and first-in-human clinical studies.

Our streamlined approach saves time, reduces complexity, 
and supports regulatory success by delivering high-quality 
data and insights across translational research. Discover how 
our in-house imaging clinics in New Haven and London can advance your program.

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Discover Our Clinical Trial Imaging Solutions

In-House Clinical and Imaging Centers

Highly established clinical and imaging centers supporting first-in-human and multicenter studies.

Imaging Core Lab

Proven expertise in delivering high-quality clinical trial imaging data at a global scale.

How Can We Help?

Reach out today and one of our solution experts will be in touch to learn about your specific needs.