Central Nervous System

Perceptive has spent nearly 30 years specializing in neuroscience imaging solutions for preclinical, early phase and late phase clinical studies.

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Overview

Our capabilities span from in vitro assays to in vivo imaging using PET, SPECT and MRI imaging biomarkers in CNS drug development and CNS clinical trials. We have expertise in coordinating worldwide multi-center imaging studies, and providing management and oversight of radiotracer supply for both commercial and non-commercially available agents. Solutions include:

 

  • Preclinical Imaging
  • Phase 0-IV Imaging Support
  • Clinical Imaging Core Lab
  • Advanced Image Analytics Including Novel IQ Analytics Suite
  • Quantitative Imaging Endpoints

CNS Expertise

Perceptive has industry leading operational oversight and extensive experience with preclinical, early phase (single-site) and late phase (multi-center) trials. This enables us to provide sponsors with unparalleled support and guidance to ensure successful study execution.

600+

Clinical CNS Imaging Trials managed. >450 AD and PD Studies with >95,000 subjects imaged

4800

Imaging Centers Qualified Worldwide

2

"In-house" Clinical Imaging Centers

140+

Development of novel neuro imaging agents

Solutions

Preclinical

A medical professional in a lab coat analyses imaging data on a computer screen, while another professional in the background reviews patient records and scans in a clinical environment.

 

Perceptive has many years of experience supporting preclinical CNS drug discovery and development programs. Our tissue biomarker services along with our functional and molecular imaging solutions are well-suited for non-invasive longitudinal studies to provide multiple readouts, such as biodistribution, target-occupancy relationships, and therapeutic efficacy.

  • Biodistribution
  • Target Engagement & Occupancy Studies
  • Neuropharmacodynamics
  • Neurotransmitter Release
  • Biological Therapeutics Pharmacokinetics
  • Neuroinflammation
  • Neuromodulator Analysis

Early Phase Clinical

 

We support a wide range of first-in-human, pre-proof of concept CNS clinical trial imaging studies spanning phases I-IIa.

MRI

  • Brain volumetric analysis
  • Changes in brain activity and cerebral blood flow
  • Tissue microstructure
  • Tissue susceptibility
  • Pharmacodynamic responses

PET

  • Radioligand dosimetry
  • Quantitative drug brain distribution
  • Target engagement
  • Drug concentration – Target occupancy relationship
  • Pharmacodynamic responses

Late Phase Clinical

A healthcare professional in scrubs sits with a patient wearing a headscarf, holding a tablet and discussing information in a bright, supportive clinical setting.

 

Perceptive’s Late Phase (IIb-IV) CNS clinical trial imaging capabilities enable the execution and delivery of large-scale clinical trials for diagnosis, progression, and disease monitoring through optimized study design, world-wide imaging site set up, iPACs driven data management and quantitative analytics. This end-to-end service is deployed in the necessary regulatory infrastructure to deliver clinical trial results ready for regulatory filing.

  • Core lab capabilities with complete project support
  • Clinical imaging center evaluation, selection, set up, training and management
  • Rapid analysis for study eligibility
  • Quantitative analysis for monitoring drug effect
  • Image data management and regulatory compliance services

Advanced Image Analytics

Two scientists discussing an image of a central nervous system scan on a computer screen.

 

We develop advanced algorithms and pipelines to solve complex image science problems, including the use of machine learning and deep learning techniques. These methods are built on our deep scientific domain knowledge to deliver optimal analytical performance and relevant biological outcome measures for a variety of tasks, including:

  • IQ Analytics Suite – Tau, Amyloid and DaT Imaging
  • Batch Image Triage & QC
  • Tracer Kinetic Analysis
  • Biomathematical Modeling
  • Image Registration, Segmentation and Volumetric Analysis
  • Radiation Dosimetry

 

 

 

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Learn about Perceptive’s extensive imaging experience and capabilities in:

Oncology

Musculoskeletal

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Radiopharmaceuticals

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