Asset Type: Discovery

Evaluating biodistribution of Zirconium-89 labeled brain derived exosomes in naïve mice comparing subpopulations using PET/CT

Evaluating biodistribution of Zirconium-89 labeled brain derived exosomes in naïve mice  comparing subpopulations using PET/CT

SNMMI 2025 Poster

Authors: Farzaneh Rezazadeh¹, Amira Hussein¹, Jacob Subik¹, Monique Nysus¹, Oslo Stanat¹, Erez Eitan², Ahmed Elsherbini², Amanda Zimmerman³, Ajay Verma³

¹ Perceptive Inc.
² NeuroDex Inc.
³
Formation Venture Engineering Foundry

Background:

Exosomes are extracellular vesicles derived from various cell types that play a crucial role in intercellular communication and have significant potential for diagnostics and therapeutics¹. Recent advances in isolation technologies have enabled the purification and extraction of cell-specific exosomes from plasma. However, understanding the in vivo biodistribution of the different subpopulations of exosomes remains crucial for optimizing their therapeutic application. Zirconium-89 offers a promising tool for positron emission tomography (PET) imaging.

In this study, we labeled both small and large exosome subpopulations with Zirconium-89 to track and evaluate their biodistribution in naïve mice using PET/CT. This research aims to provide valuable insights into the in vivo distribution patterns of differently sized exosomes, which is essential for optimizing their application in diagnostics and therapeutic delivery.

SNMMI 2025 Poster

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