New Study Validates PET Imaging of MC1 as a Biomarker for Friedreich Ataxia:
A new study published in The Journal of Nuclear Medicine demonstrates the use of [¹⁸F]BCPP-EF PET imaging to measure mitochondrial complex I (MC1) density in both the heart and brain of individuals with Friedreich ataxia (FA). Developed through a collaboration between Pfizer and Perceptive, the study includes both murine and human data and highlights MC1 as a promising noninvasive biomarker for disease monitoring and potential therapeutic response.
This work exemplifies how advanced preclinical and translational imaging methods can support biomarker discovery and clinical development in rare diseases. Learn more about our capabilities in preclinical imaging that support this type of research.
Why Read this Publication:
- Demonstrates [¹⁸F]BCPP-EF PET imaging as a noninvasive method to assess mitochondrial complex I (MC1) density in Friedreich ataxia.
- Reveals significant correlations between MC1 density, frataxin levels, and GAA repeat length in both humans and a mouse model.
- Proposes a practical imaging protocol to evaluate cardiac and brain MC1 in a single clinical visit.