Authors: Farzaneh Rezazadeh¹, Amira Hussein¹, Jacob Subik¹, Monique Nysus¹, Oslo Stanat¹, Erez Eitan², Ahmed Elsherbini², Amanda Zimmerman³, Ajay Verma³
¹ Perceptive Inc. ² NeuroDex Inc. ³ Formation Venture Engineering Foundry
Exosomes are extracellular vesicles derived from various cell types that play a crucial role in intercellular communication and have significant potential for diagnostics and therapeutics¹. Recent advances in isolation technologies have enabled the purification and extraction of cell-specific exosomes from plasma. However, understanding the in vivo biodistribution of the different subpopulations of exosomes remains crucial for optimizing their therapeutic application. Zirconium-89 offers a promising tool for positron emission tomography (PET) imaging.
In this study, we labeled both small and large exosome subpopulations with Zirconium-89 to track and evaluate their biodistribution in naïve mice using PET/CT. This research aims to provide valuable insights into the in vivo distribution patterns of differently sized exosomes, which is essential for optimizing their application in diagnostics and therapeutic delivery.
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